Scaling graphs of heart rate time series in athletes demonstrate the VLF, LF and HF regions

Scaling analysis of heart rate time series has emerged as an useful tool for assessment of autonomic cardiac control. We investigate the heart rate time series of ten athletes (five males and five females), by applying detrended fluctuation analysis (DFA). High resolution ECGs are recorded under standardized resting conditions over 30 minutes and subsequently heart rate time series are extracted and artefacts filtered. We find three distinct regions of scale-invariance, which correspond to the well-known VLF, LF, and HF bands in the power spectra of heart rate variability. The scaling exponents alpha are alphaHF: 1.15 [0.96-1.22], alphaLF: 0.68 [0.57-0.84], alphaVLF: 0.83[0.82-0.99]; p<10^-5). In conclusion, DFA scaling exponents of heart rate time series should be fitted to the VLF, LF, and HF ranges, respectively

Remote Detection of Saline Intrusion in a Coastal Aquifer Using Borehole Measurements of Self-Potential

Funded by NERC CASE studentship . Grant Number: NE/I018417/1Peer reviewedPublisher PD

Sex-partitioning of the <i>Plasmodium falciparum</i> stage V gametocyte proteome provides insight into <i>falciparum</i>-specific cell biology

One of the critical gaps in malaria transmission biology and surveillance is our lack of knowledge about Plasmodium falciparum gametocyte biology, especially sexual dimorphic development and how sex ratios that may influence transmission from the human to the mosquito. Dissecting this process has been hampered by the lack of sex-specific protein markers for the circulating, mature stage V gametocytes. The current evidence suggests a high degree of conservation in gametocyte gene complement across Plasmodium, and therefore presumably for sex-specific genes as well. To better our understanding of gametocyte development and subsequent infectiousness to mosquitoes, we undertook a Systematic Subtractive Bioinformatic analysis (filtering) approach to identify sex-specific P. falciparum NF54 protein markers based on a comparison with the Dd2 strain, which is defective in producing males, and with syntenic male and female proteins from the reanalyzed and updated P. berghei (related rodent malaria parasite) gametocyte proteomes. This produced a short list of 174 male- and 258 female-enriched P. falciparum stage V proteins, some of which appear to be under strong diversifying selection, suggesting ongoing adaptation to mosquito vector species. We generated antibodies against three putative female-specific gametocyte stage V proteins in P. falciparum and confirmed either conserved sex-specificity or the lack of cross-species sex-partitioning. Finally, our study provides not only an additional resource for mass spectrometry-derived evidence for gametocyte proteins but also lays down the foundation for rational screening and development of novel sex-partitioned protein biomarkers and transmission-blocking vaccine candidates

Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis comprising 18,506 patients

© 2020, Hellenic Endocrine Society. Purpose: Infectious diseases are more frequent and can be associated with worse outcomes in patients with diabetes. The aim of this study was to systematically review and conduct a meta-analysis of the available observational studies reporting the effect of diabetes on mortality among hospitalized patients with COVID-19. Methods: The Medline, Embase, Google Scholar, and medRxiv databases were reviewed for identification of eligible studies. A random effects model meta-analysis was used, and I2 was utilized to assess the heterogeneity. In-hospital mortality was defined as the endpoint. Sensitivity, subgroup, and meta-regression analyses were performed. Results: A total of 18,506 patients were included in this meta-analysis (3713 diabetics and 14,793 non-diabetics). Patients with diabetes were associated with a higher risk of death compared with patients without diabetes (OR 1.65; 95% CI 1.35–1.96; I2 77.4%). The heterogeneity was high. A study-level meta-regression analysis was performed for all the important covariates, and no significant interactions were found between the covariates and the outcome of mortality. Conclusion: This meta-analysis shows that that the likelihood of death seems to be higher in diabetic patients hospitalized with COVID-19 compared with non-diabetic patients. Further studies are needed to assess whether this association is independent or not, as well as to investigate the role of adequate glycemic control prior to infection with COVID-19

HD 51106 and HD 50747: an ellipsoidal binary and a triple system observed with CoRoT

We present an analysis of the observations of HD 51106 and HD 50747 by the satellite CoRoT, obtained during its initial run, and of the spectroscopic preparatory observations. AIMS: We complete an analysis of the light curve, extract the main frequencies observed, and discuss some preliminary interpretations about the stars. Methods: We used standard Fourier transform and pre-whitening methods to extract information about the periodicities of the stars. Results: HD 51106 is an ellipsoidal binary, the light curve of which can be completely explained by the tidal deformation of the star and smaller secondary effects. HD 50747 is a triple system containing a variable star, which exhibits many modes of oscillation with periods in the range of a few hours. On the basis of this period range and the analysis of the physical parameters of the star, we conclude that HD 50747 is a Gamma-Doradus star.Comment: 7 pages, 8 figures, use (Astronomy-Astrophysics format/macro LAtex

Retardation turns the van der Waals attraction into Casimir repulsion already at 3 nm

Casimir forces between surfaces immersed in bromobenzene have recently been measured by Munday et al. Attractive Casimir forces were found between gold surfaces. The forces were repulsive between gold and silica surfaces. We show the repulsion is due to retardation effects. The van der Waals interaction is attractive at all separations. The retardation driven repulsion sets in already at around 3 nm. To our knowledge retardation effects have never been found at such a small distance before. Retardation effects are usually associated with large distances

Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity

Individual diversity at the major histocompatibility complex (MHC) is predicted to be optimal at intermediate rather than at maximal levels. We showed previously in sticklebacks that an intermediate MHC diversity is predominant in natural populations and provides maximal resistance in experimental multiple parasite infections in the laboratory. However, what counts ultimately is the lifetime reproductive success (LRS). Here, we measured LRS of six laboratory-bred sib-groups—to minimize the influence of non-MHC genes—three-spined sticklebacks (Gasterosteus aculeatus) during their entire breeding period, each in a seminatural enclosure in the lake of their parents, where they were exposed to the natural spectrum of parasites. We collected developing clutches at regular intervals and determined parenthood for a representative number of eggs (2279 in total) per clutch with 18 microsatellites. Both males and females with an intermediate MHC class IIB variant number had the highest LRS. The mechanistic link of MHC diversity and LRS differed between the sexes: in females, we found evidence for a trade-off between number of eggs and immunocompentence, whereas in males this correlation was concealed by different timing strategies of reproduction

Testing Rotational Mixing Predictions with New Boron Abundances in Main Sequence B-type Stars

(Abridged) New boron abundances for seven main-sequence B-type stars are determined from HST STIS spectroscopy around the BIII 2066A line. Boron abundances provide a unique and critical test of stellar evolution models that include rotational mixing since boron is destroyed in the surface layers of stars through shallow mixing long before other elements are mixed from the stellar interior through deep mixing. Boron abundances range from 12+log(B/H) = 1.0 to 2.2. The boron abundances are compared to the published values of their stellar nitrogen abundances (all have 12+log(N/H) < 7.8, i.e., they do not show significant CNO-mixing) and to their host cluster ages (4 to 16 Myr) to investigate the predictions from models of massive star evolution with rotational mixing effects (Heger & Langer 2000). Only three stars (out of 34) deviate from the model predictions, including HD36591, HD205021, and HD30836. These three stars suggest that rotational mixing could be more efficient than currently modelled at the highest rotation rates.Comment: 10 figures, 7 tables; accepted for publication in the Astrophysical Journa